溶出数据处理

达格列净二甲双胍缓释片项目信息

介质体积(ml)	1000	取样体积(ml)	5	补液体积(ml)	5
对照品批号	100664-202106	对照品来源	中检院	对照品使用方法	直接使用
对照品含量(%)	100	对照品水分(%)	0	对照品稀释倍数	50
标示量(mg)	1000	供试品稀释倍数	5	系数	1

对照品溶液

序号	称样量(mg)	A₁	A₂	A₃	A₄	A₅	A_平均	RSD%
1	10.35	4260309	4261313	4259093	4260806	4270984	4262501	0.12
2	10.37	4289715	4297120				4293418	0.13

单位质量响应值		RSD%	判断
411835.85	414022.95	0.38	数据可信

供试品溶液-YA0011批-二甲双胍-pH6.8

时间 (分钟)	样品	A₁	A₂	A_平均	溶出量(%)	平均(%)	RSD%	累计溶出量(%)	平均(%)	RSD%
5min	1	112450	-	112450	2.723	2.85	6.49	2.72	2.84	6.45
	2	109405	-	109405	2.650			2.65
	3	111769	-	111769	2.707			2.71
	4	121990	-	121990	2.954			2.95
	5	120209	-	120209	2.911			2.91
	6	129346	-	129346	3.132			3.13
10min	1	277393	-	277393	6.718	6.88	4.77	6.73	6.89	4.73
	2	279823	-	279823	6.777			6.79
	3	284170	-	284170	6.882			6.90
	4	303873	-	303873	7.359			7.37
	5	293470	-	293470	7.107			7.12
	6	264711	-	264711	6.411			6.43
15min	1	413925	-	413925	10.024	10.40	6.15	10.07	10.44	6.11
	2	423672	-	423672	10.260			10.31
	3	441570	-	441570	10.694			10.74
	4	434530	-	434530	10.523			10.57
	5	470033	-	470033	11.383			11.43
	6	392205	-	392205	9.498			9.55
20min	1	540028	-	540028	13.078	13.09	2.91	13.18	13.19	2.91
	2	548625	-	548625	13.286			13.38
	3	549277	-	549277	13.302			13.40
	4	544926	-	544926	13.197			13.30
	5	550401	-	550401	13.329			13.44
	6	509314	-	509314	12.334			12.43
30min	1	737012	-	737012	17.849	17.89	2.67	18.01	18.06	2.68
	2	750685	-	750685	18.180			18.34
	3	745913	-	745913	18.064			18.23
	4	747369	-	747369	18.099			18.27
	5	752119	-	752119	18.214			18.39
	6	700226	-	700226	16.958			17.11
45min	1	988313	-	988313	23.934	24.22	2.44	24.19	24.47	2.43
	2	1013973	-	1013973	24.556			24.81
	3	1022983	-	1022983	24.774			25.03
	4	1017160	-	1017160	24.633			24.89
	5	1000352	-	1000352	24.226			24.49
	6	957586	-	957586	23.190			23.43
60min	1	1196558	-	1196558	28.978	28.93	1.95	29.35	29.31	1.95
	2	1212098	-	1212098	29.354			29.73
	3	1219546	-	1219546	29.534			29.92
	4	1197826	-	1197826	29.008			29.39
	5	1189230	-	1189230	28.800			29.19
	6	1152889	-	1152889	27.920			28.28
120min	1	1886692	-	1886692	45.691	44.96	1.72	46.21	45.48	1.72
	2	1875027	-	1875027	45.408			45.93
	3	1880577	-	1880577	45.543			46.07
	4	1832752	-	1832752	44.384			44.91
	5	1858305	-	1858305	45.003			45.53
	6	1805004	-	1805004	43.712			44.21
180min	1	2318631	-	2318631	56.151	56.22	1.35	56.90	56.97	1.35
	2	2364417	-	2364417	57.260			58.01
	3	2350566	-	2350566	56.925			57.68
	4	2310886	-	2310886	55.964			56.71
	5	2305792	-	2305792	55.840			56.60
	6	2278668	-	2278668	55.183			55.90

时间 (分钟)	样品	A₁	A₂	A_平均	溶出量(%)	平均(%)	RSD%	累计溶出量(%)	平均(%)	RSD%
240min	1	2708564	-	2708564	65.594	65.42	1.16	66.62	66.44	1.16
	2	2744393	-	2744393	66.462			67.50
	3	2720569	-	2720569	65.885			66.93
	4	2698773	-	2698773	65.357			66.39
	5	2654605	-	2654605	64.288			65.32
	6	2680480	-	2680480	64.914			65.91
360min	1	3256824	-	3256824	78.872	78.72	1.19	80.23	80.08	1.18
	2	3275261	-	3275261	79.318			80.69
	3	3246034	-	3246034	78.610			79.98
	4	3307087	-	3307087	80.089			81.45
	5	3213625	-	3213625	77.826			79.18
	6	3204330	-	3204330	77.600			78.92
480min	1	3612188	-	3612188	87.478	87.50	1.10	89.23	89.24	1.09
	2	3653402	-	3653402	88.476			90.24
	3	3618729	-	3618729	87.636			89.40
	4	3643785	-	3643785	88.243			90.00
	5	3541175	-	3541175	85.758			87.50
	6	3608903	-	3608903	87.398			89.10
600min	1	3794147	-	3794147	91.884	92.43	1.32	94.07	94.62	1.31
	2	3872762	-	3872762	93.788			96.00
	3	3861866	-	3861866	93.524			95.73
	4	3846134	-	3846134	93.143			95.34
	5	3772915	-	3772915	91.370			93.54
	6	3753083	-	3753083	90.890			93.03
720min	1	3915775	-	3915775	94.830	94.36	0.85	97.47	97.01	0.85
	2	3890596	-	3890596	94.220			96.90
	3	3929513	-	3929513	95.163			97.83
	4	3925457	-	3925457	95.064			97.73
	5	3869217	-	3869217	93.702			96.33
	6	3848594	-	3848594	93.203			95.80
极限	1	3886167	-	3886167	94.113	94.56	1.33	97.23	97.68	1.32
	2	3959798	-	3959798	95.896			99.05
	3	3927269	-	3927269	95.108			98.25
	4	3959496	-	3959496	95.889			99.03
	5	3844182	-	3844182	93.096			96.19
	6	3851906	-	3851906	93.283			96.34

达格列净二甲双胍缓释片项目信息

介质体积(ml)	1000	取样体积(ml)	5	补液体积(ml)	5
对照品批号	101568-202301	对照品来源	中检院	对照品使用方法	直接使用
对照品含量(%)	80.4	对照品水分(%)	0	对照品稀释倍数	12500
标示量(mg)	5	供试品稀释倍数	5	系数	1

对照品溶液

序号	称样量(mg)	A₁	A₂	A₃	A₄	A₅	A_平均	RSD%
1	12.51	15787	15719	15802	15867	15947	15824	0.55
2	12.54	15913	15815				15864	0.44

单位质量响应值		RSD%	判断
1264.91	1265.07	0.01	数据可信

供试品溶液-YA0011批-达格列净-pH6.8

时间 (分钟)	样品	A₁	A₂	A_平均	溶出量(%)	平均(%)	RSD%	累计溶出量(%)	平均(%)	RSD%
5min	1	12970	-	12970	65.948	69.23	9.28	65.95	69.23	9.28
	2	13579	-	13579	69.044			69.04
	3	13751	-	13751	69.919			69.92
	4	14204	-	14204	72.222			72.22
	5	15494	-	15494	78.781			78.78
	6	11700	-	11700	59.490			59.49
10min	1	17875	-	17875	90.888	93.83	4.13	91.22	94.18	4.13
	2	18761	-	18761	95.393			95.74
	3	19858	-	19858	100.970			101.32
	4	18211	-	18211	92.596			92.96
	5	18161	-	18161	92.342			92.74
	6	17856	-	17856	90.791			91.09
15min	1	18202	-	18202	92.550	95.41	3.55	93.33	96.22	3.55
	2	18869	-	18869	95.942			96.76
	3	19942	-	19942	101.398			102.25
	4	18885	-	18885	96.023			96.85
	5	18588	-	18588	94.513			95.37
	6	18095	-	18095	92.006			92.76
20min	1	18509	-	18509	94.111	95.54	3.35	95.36	96.84	3.34
	2	18899	-	18899	96.094			97.40
	3	20013	-	20013	101.759			103.12
	4	18465	-	18465	93.888			95.19
	5	18324	-	18324	93.171			94.50
	6	18535	-	18535	94.244			95.45
30min	1	18410	-	18410	93.608	95.62	2.48	95.33	97.40	2.49
	2	18903	-	18903	96.115			97.90
	3	19691	-	19691	100.121			101.99
	4	18537	-	18537	94.254			96.03
	5	18719	-	18719	95.179			96.97
	6	18579	-	18579	94.467			96.15
45min	1	18345	-	18345	93.277	96.16	3.37	95.46	98.41	3.35
	2	19301	-	19301	98.138			100.40
	3	20007	-	20007	101.728			104.10
	4	18756	-	18756	95.367			97.61
	5	18386	-	18386	93.486			95.76
	6	18681	-	18681	94.986			97.14
60min	1	17863	-	17863	90.827	94.51	3.84	93.48	97.24	3.81
	2	18620	-	18620	94.676			97.43
	3	19942	-	19942	101.398			104.28
	4	18290	-	18290	92.998			95.72
	5	18293	-	18293	93.013			95.75
	6	18515	-	18515	94.142			96.77
120min	1	18775	-	18775	95.464	95.86	2.92	98.57	99.06	2.91
	2	18861	-	18861	95.901			99.13
	3	19862	-	19862	100.991			104.38
	4	18186	-	18186	92.469			95.66
	5	18734	-	18734	95.255			98.46
	6	18695	-	18695	95.057			98.16
180min	1	18103	-	18103	92.047	94.47	2.94	95.63	98.16	2.92
	2	18935	-	18935	96.277			99.98
	3	19468	-	19468	98.987			102.88
	4	18200	-	18200	92.540			96.19
	5	18137	-	18137	92.220			95.90
	6	18640	-	18640	94.777			98.35

时间 (分钟)	样品	A₁	A₂	A_平均	溶出量(%)	平均(%)	RSD%	累计溶出量(%)	平均(%)	RSD%
240min	1	18021	-	18021	91.630	93.94	2.94	95.67	98.10	2.91
	2	18885	-	18885	96.023			100.21
	3	19235	-	19235	97.803			102.19
	4	18369	-	18369	93.399			97.51
	5	17772	-	17772	90.364			94.50
	6	18574	-	18574	94.442			98.49
360min	1	18020	-	18020	91.625	94.27	2.50	96.13	98.89	2.50
	2	18571	-	18571	94.427			99.09
	3	19352	-	19352	98.398			103.27
	4	18592	-	18592	94.533			99.11
	5	18175	-	18175	92.413			97.00
	6	18529	-	18529	94.213			98.74
480min	1	18135	-	18135	92.210	93.25	2.51	97.17	98.34	2.50
	2	18540	-	18540	94.269			99.41
	3	19091	-	19091	97.071			102.44
	4	17894	-	17894	90.984			96.04
	5	17903	-	17903	91.030			96.08
	6	18473	-	18473	93.928			98.92
600min	1	17495	-	17495	88.956	92.88	3.25	94.38	98.44	3.22
	2	18727	-	18727	95.220			100.83
	3	19172	-	19172	97.482			103.34
	4	18166	-	18166	92.367			97.87
	5	17996	-	17996	91.503			97.01
	6	18046	-	18046	91.757			97.22
720min	1	17690	-	17690	89.947	92.23	2.86	95.81	98.26	2.85
	2	18275	-	18275	92.922			99.01
	3	19120	-	19120	97.218			103.56
	4	17869	-	17869	90.857			96.83
	5	17897	-	17897	91.000			96.97
	6	17985	-	17985	91.447			97.37
极限	1	17324	-	17324	88.086	91.16	3.49	94.40	97.64	3.44
	2	18203	-	18203	92.555			99.11
	3	19024	-	19024	96.730			103.56
	4	17754	-	17754	90.272			96.69
	5	17402	-	17402	88.483			94.90
	6	17861	-	17861	90.816			97.20

达格列净二甲双胍缓释片项目信息

介质体积(ml)	1000	取样体积(ml)	5	补液体积(ml)	5
对照品批号	100664-202106	对照品来源	中检院	对照品使用方法	直接使用
对照品含量(%)	100	对照品水分(%)	0	对照品稀释倍数	50
标示量(mg)	1000	供试品稀释倍数	5	系数	1

对照品溶液

序号	称样量(mg)	A₁	A₂	A₃	A₄	A₅	A_平均	RSD%
1	10.35	4363659	4368613	4357615	4355547	4355685	4360224	0.14
2	10.37	4376956	4315775				4346366	1.00

单位质量响应值		RSD%	判断
421277.68	419128.83	0.37	数据可信

供试品溶液-YA0011批-二甲双胍-pH6.8

时间 (分钟)	样品	A₁	A₂	A_平均	溶出量(%)	平均(%)	RSD%	累计溶出量(%)	平均(%)	RSD%
5min	1	136128	-	136128	3.240	2.85	9.84	3.24	2.85	9.85
	2	123289	-	123289	2.934			2.93
	3	106909	-	106909	2.544			2.54
	4	113737	-	113737	2.707			2.71
	5	129984	-	129984	3.093			3.09
	6	109353	-	109353	2.602			2.60
10min	1	278795	-	278795	6.635	6.60	2.90	6.65	6.62	2.92
	2	292119	-	292119	6.952			6.97
	3	276401	-	276401	6.578			6.59
	4	268719	-	268719	6.395			6.41
	5	276761	-	276761	6.586			6.60
	6	272159	-	272159	6.477			6.49
15min	1	420206	-	420206	10.000	10.05	3.09	10.05	10.10	3.08
	2	433597	-	433597	10.319			10.37
	3	424641	-	424641	10.106			10.15
	4	425909	-	425909	10.136			10.18
	5	431537	-	431537	10.270			10.32
	6	397520	-	397520	9.460			9.51
20min	1	541958	-	541958	12.898	12.67	2.64	13.00	12.77	2.64
	2	549711	-	549711	13.082			13.18
	3	526812	-	526812	12.537			12.63
	4	517251	-	517251	12.310			12.41
	5	542573	-	542573	12.912			13.01
	6	517271	-	517271	12.310			12.40
30min	1	744491	-	744491	17.718	17.42	2.61	17.88	17.58	2.61
	2	758774	-	758774	18.057			18.22
	3	733064	-	733064	17.446			17.60
	4	708215	-	708215	16.854			17.01
	5	735005	-	735005	17.492			17.66
	6	712679	-	712679	16.960			17.11
45min	1	968641	-	968641	23.052	23.21	2.91	23.30	23.46	2.91
	2	1005524	-	1005524	23.930			24.19
	3	1005050	-	1005050	23.918			24.16
	4	948088	-	948088	22.563			22.80
	5	985485	-	985485	23.453			23.70
	6	938802	-	938802	22.342			22.58
60min	1	1172354	-	1172354	27.900	27.84	1.92	28.27	28.21	1.93
	2	1193424	-	1193424	28.401			28.78
	3	1187577	-	1187577	28.262			28.63
	4	1145361	-	1145361	27.257			27.61
	5	1181676	-	1181676	28.122			28.49
	6	1139763	-	1139763	27.124			27.48
120min	1	1827590	-	1827590	43.493	43.09	1.64	44.00	43.59	1.64
	2	1823612	-	1823612	43.399			43.92
	3	1805850	-	1805850	42.976			43.48
	4	1801259	-	1801259	42.867			43.36
	5	1845199	-	1845199	43.912			44.42
	6	1759423	-	1759423	41.871			42.36
180min	1	2300838	-	2300838	54.756	54.64	1.57	55.48	55.36	1.56
	2	2300908	-	2300908	54.757			55.49
	3	2300347	-	2300347	54.744			55.47
	4	2260261	-	2260261	53.790			54.50
	5	2356280	-	2356280	56.075			56.80
	6	2257918	-	2257918	53.734			54.43

时间 (分钟)	样品	A₁	A₂	A_平均	溶出量(%)	平均(%)	RSD%	累计溶出量(%)	平均(%)	RSD%
240min	1	2746767	-	2746767	65.368	63.34	1.91	66.37	64.33	1.90
	2	2619742	-	2619742	62.345			63.35
	3	2667532	-	2667532	63.482			64.48
	4	2634701	-	2634701	62.701			63.68
	5	2688107	-	2688107	63.972			64.98
	6	2612534	-	2612534	62.174			63.14
360min	1	3203436	-	3203436	76.236	76.22	1.27	77.56	77.52	1.26
	2	3193646	-	3193646	76.003			77.32
	3	3219264	-	3219264	76.613			77.93
	4	3138542	-	3138542	74.692			75.98
	5	3263494	-	3263494	77.665			78.99
	6	3197620	-	3197620	76.097			77.37
480min	1	3624692	-	3624692	86.261	85.23	1.08	87.97	86.92	1.08
	2	3539794	-	3539794	84.241			85.94
	3	3622193	-	3622193	86.202			87.90
	4	3556131	-	3556131	84.629			86.29
	5	3598627	-	3598627	85.641			87.36
	6	3546421	-	3546421	84.398			86.05
600min	1	3819216	-	3819216	90.890	90.57	0.88	93.03	92.69	0.87
	2	3747249	-	3747249	89.178			91.30
	3	3833151	-	3833151	91.222			93.35
	4	3785560	-	3785560	90.089			92.17
	5	3826788	-	3826788	91.071			93.22
	6	3823684	-	3823684	90.997			93.07
720min	1	3885544	-	3885544	92.469	92.32	0.80	95.06	94.88	0.80
	2	3924271	-	3924271	93.390			95.96
	3	3885150	-	3885150	92.459			95.04
	4	3868026	-	3868026	92.052			94.59
	5	3882429	-	3882429	92.395			95.00
	6	3829079	-	3829079	91.125			93.66
极限	1	3882965	-	3882965	92.407	92.34	0.63	95.46	95.37	0.62
	2	3838868	-	3838868	91.358			94.39
	3	3892384	-	3892384	92.632			95.68
	4	3865243	-	3865243	91.986			94.98
	5	3903098	-	3903098	92.887			95.95
	6	3898519	-	3898519	92.778			95.77

达格列净二甲双胍缓释片项目信息

介质体积(ml)	1000	取样体积(ml)	5	补液体积(ml)	5
对照品批号	101568-202301	对照品来源	中检院	对照品使用方法	直接使用
对照品含量(%)	80.4	对照品水分(%)	0	对照品稀释倍数	12500
标示量(mg)	5	供试品稀释倍数	5	系数	1

对照品溶液

序号	称样量(mg)	A₁	A₂	A₃	A₄	A₅	A_平均	RSD%
1	12.51	16275	16088	16074	16030	16019	16097	0.65
2	12.54	15744	15919				15832	0.79

单位质量响应值		RSD%	判断
1286.73	1262.52	1.35	数据可信

供试品溶液-YA0011批-达格列净-pH6.8

时间 (分钟)	样品	A₁	A₂	A_平均	溶出量(%)	平均(%)	RSD%	累计溶出量(%)	平均(%)	RSD%
5min	1	13646	-	13646	68.867	66.96	7.72	68.87	66.96	7.72
	2	14463	-	14463	72.990			72.99
	3	14190	-	14190	71.612			71.61
	4	12502	-	12502	63.093			63.09
	5	13020	-	13020	65.707			65.71
	6	11793	-	11793	59.515			59.52
10min	1	18004	-	18004	90.860	89.98	2.99	91.20	90.32	3.00
	2	18557	-	18557	93.651			94.02
	3	18184	-	18184	91.768			92.13
	4	17075	-	17075	86.171			86.49
	5	17450	-	17450	88.064			88.39
	6	17711	-	17711	89.381			89.68
15min	1	18350	-	18350	92.606	92.36	3.02	93.40	93.15	3.03
	2	18676	-	18676	94.251			95.08
	3	18935	-	18935	95.558			96.38
	4	17359	-	17359	87.605			88.35
	5	18037	-	18037	91.026			91.80
	6	18454	-	18454	93.131			93.88
20min	1	18760	-	18760	94.675	93.21	2.15	95.94	94.46	2.16
	2	18894	-	18894	95.351			96.66
	3	18511	-	18511	93.418			94.71
	4	17777	-	17777	89.714			90.90
	5	18300	-	18300	92.354			93.58
	6	18578	-	18578	93.757			94.97
30min	1	18807	-	18807	94.912	93.21	3.94	96.65	94.92	3.92
	2	19365	-	19365	97.728			99.51
	3	18609	-	18609	93.913			95.67
	4	17251	-	17251	87.060			88.69
	5	18072	-	18072	91.203			92.89
	6	18713	-	18713	94.438			96.12
45min	1	18068	-	18068	91.183	91.55	2.73	93.39	93.73	2.74
	2	18627	-	18627	94.004			96.27
	3	18736	-	18736	94.554			96.79
	4	17370	-	17370	87.660			89.73
	5	18067	-	18067	91.178			93.32
	6	17979	-	17979	90.734			92.88
60min	1	18263	-	18263	92.167	91.83	2.61	94.83	94.47	2.62
	2	18835	-	18835	95.054			97.79
	3	18541	-	18541	93.570			96.27
	4	17532	-	17532	88.478			90.98
	5	17807	-	17807	89.866			92.46
	6	18203	-	18203	91.864			94.47
120min	1	18444	-	18444	93.080	91.67	2.12	96.21	94.77	2.14
	2	18598	-	18598	93.857			97.07
	3	18179	-	18179	91.743			94.91
	4	17561	-	17561	88.624			91.57
	5	17877	-	17877	90.219			93.27
	6	18332	-	18332	92.515			95.58
180min	1	18350	-	18350	92.606	92.39	2.05	96.20	95.94	2.06
	2	18765	-	18765	94.700			98.38
	3	18327	-	18327	92.490			96.12
	4	17656	-	17656	89.104			92.50
	5	18208	-	18208	91.889			95.39
	6	18535	-	18535	93.540			97.07

时间 (分钟)	样品	A₁	A₂	A_平均	溶出量(%)	平均(%)	RSD%	累计溶出量(%)	平均(%)	RSD%
240min	1	18670	-	18670	94.221	91.88	2.43	98.28	95.89	2.43
	2	18341	-	18341	92.561			96.72
	3	18495	-	18495	93.338			97.43
	4	17441	-	17441	88.019			91.86
	5	17959	-	17959	90.633			94.59
	6	18326	-	18326	92.485			96.48
360min	1	18254	-	18254	92.121	91.21	3.39	96.65	95.68	3.35
	2	18502	-	18502	93.373			97.99
	3	18567	-	18567	93.701			98.26
	4	17010	-	17010	85.843			90.12
	5	17680	-	17680	89.225			93.64
	6	18425	-	18425	92.984			97.44
480min	1	18400	-	18400	92.858	91.54	2.48	97.84	96.47	2.48
	2	18402	-	18402	92.868			97.96
	3	18575	-	18575	93.741			98.77
	4	17495	-	17495	88.291			93.00
	5	17654	-	17654	89.093			93.95
	6	18306	-	18306	92.384			97.31
600min	1	18189	-	18189	91.793	91.09	2.39	97.24	96.47	2.37
	2	18283	-	18283	92.268			97.82
	3	18252	-	18252	92.111			97.61
	4	17524	-	17524	88.437			93.59
	5	17507	-	17507	88.352			93.65
	6	18537	-	18537	93.550			98.93
720min	1	17996	-	17996	90.819	90.67	3.18	96.73	96.51	3.12
	2	18759	-	18759	94.670			100.68
	3	18225	-	18225	91.975			97.93
	4	17440	-	17440	88.013			93.60
	5	17190	-	17190	86.752			92.50
	6	18188	-	18188	91.788			97.64
极限	1	17904	-	17904	90.355	89.93	2.13	96.72	96.22	2.15
	2	18263	-	18263	92.167			98.65
	3	17826	-	17826	89.961			96.38
	4	17224	-	17224	86.923			92.95
	5	17568	-	17568	88.659			94.84
	6	18131	-	18131	91.501			97.81

点击查看处理图标(人工保存)

图1　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-溶剂
图2　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-对照品溶液-1-1
图3　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-对照品溶液-1-2
图4　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-对照品溶液-1-3
图5　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-对照品溶液-1-4
图6　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-对照品溶液-1-5
图7　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-5min-片1-供试品溶液-1
图8　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-5min-片2-供试品溶液-1
图9　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-5min-片3-供试品溶液-1
图10　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-5min-片4-供试品溶液-1
图11　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-5min-片5-供试品溶液-1
图12　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-5min-片6-供试品溶液-1
图13　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-10min-片1-供试品溶液-1
图14　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-10min-片2-供试品溶液-1
图15　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-10min-片3-供试品溶液-1
图16　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-10min-片4-供试品溶液-1
图17　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-10min-片5-供试品溶液-1
图18　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-10min-片6-供试品溶液-1
图19　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-15min-片1-供试品溶液-1
图20　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-15min-片2-供试品溶液-1
图21　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-15min-片3-供试品溶液-1
图22　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-15min-片4-供试品溶液-1
图23　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-15min-片5-供试品溶液-1
图24　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-15min-片6-供试品溶液-1
图25　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-20min-片1-供试品溶液-1
图26　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-20min-片2-供试品溶液-1
图27　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-20min-片3-供试品溶液-1
图28　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-20min-片4-供试品溶液-1
图29　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-20min-片5-供试品溶液-1
图30　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-20min-片6-供试品溶液-1
图31　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-30min-片1-供试品溶液-1
图32　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-30min-片2-供试品溶液-1
图33　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-30min-片3-供试品溶液-1
图34　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-30min-片4-供试品溶液-1
图35　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-30min-片5-供试品溶液-1
图36　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-30min-片6-供试品溶液-1
图37　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-45min-片1-供试品溶液-1
图38　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-45min-片2-供试品溶液-1
图39　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-45min-片3-供试品溶液-1
图40　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-45min-片4-供试品溶液-1
图41　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-45min-片5-供试品溶液-1
图42　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-45min-片6-供试品溶液-1
图43　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-60min-片1-供试品溶液-1
图44　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-60min-片2-供试品溶液-1
图45　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-60min-片3-供试品溶液-1
图46　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-60min-片4-供试品溶液-1
图47　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-60min-片5-供试品溶液-1
图48　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-60min-片6-供试品溶液-1
图49　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-120min-片1-供试品溶液-1
图50　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-120min-片2-供试品溶液-1
图51　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-120min-片3-供试品溶液-1
图52　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-120min-片4-供试品溶液-1
图53　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-120min-片5-供试品溶液-1
图54　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-120min-片6-供试品溶液-1
图55　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-180min-片1-供试品溶液-1
图56　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-180min-片2-供试品溶液-1
图57　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-180min-片3-供试品溶液-1
图58　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-180min-片4-供试品溶液-1
图59　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-180min-片5-供试品溶液-1
图60　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-180min-片6-供试品溶液-1
图61　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-240min-片1-供试品溶液-1
图62　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-240min-片2-供试品溶液-1
图63　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-240min-片3-供试品溶液-1
图64　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-240min-片4-供试品溶液-1
图65　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-240min-片5-供试品溶液-1
图66　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-240min-片6-供试品溶液-1
图67　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-360min-片1-供试品溶液-1
图68　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-360min-片2-供试品溶液-1
图69　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-360min-片3-供试品溶液-1
图70　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-360min-片4-供试品溶液-1
图71　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-360min-片5-供试品溶液-1
图72　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-360min-片6-供试品溶液-1
图73　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-480min-片1-供试品溶液-1
图74　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-480min-片2-供试品溶液-1
图75　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-480min-片3-供试品溶液-1
图76　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-480min-片4-供试品溶液-1
图77　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-480min-片5-供试品溶液-1
图78　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-480min-片6-供试品溶液-1
图79　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-600min-片1-供试品溶液-1
图80　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-600min-片2-供试品溶液-1
图81　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-600min-片3-供试品溶液-1
图82　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-600min-片4-供试品溶液-1
图83　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-600min-片5-供试品溶液-1
图84　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-600min-片6-供试品溶液-1
图85　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-720min-片1-供试品溶液-1
图86　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-720min-片2-供试品溶液-1
图87　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-720min-片3-供试品溶液-1
图88　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-720min-片4-供试品溶液-1
图89　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-720min-片5-供试品溶液-1
图90　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-720min-片6-供试品溶液-1
图91　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-极限转速-片1-供试品溶液-1
图92　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-极限转速-片2-供试品溶液-1
图93　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-极限转速-片3-供试品溶液-1
图94　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-极限转速-片4-供试品溶液-1
图95　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-极限转速-片5-供试品溶液-1
图96　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-极限转速-片6-供试品溶液-1
图97　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-对照品溶液-2-1
图98　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性1-pH6.8介质-篮法-100转-对照品溶液-2-2
图99　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-溶剂
图100　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-对照品溶液-1-1
图101　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-对照品溶液-1-2
图102　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-对照品溶液-1-3
图103　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-对照品溶液-1-4
图104　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-对照品溶液-1-5
图105　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-5min-片1-供试品溶液-1
图106　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-5min-片2-供试品溶液-1
图107　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-5min-片3-供试品溶液-1
图108　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-5min-片4-供试品溶液-1
图109　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-5min-片5-供试品溶液-1
图110　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-5min-片6-供试品溶液-1
图111　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-10min-片1-供试品溶液-1
图112　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-10min-片2-供试品溶液-1
图113　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-10min-片3-供试品溶液-1
图114　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-10min-片4-供试品溶液-1
图115　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-10min-片5-供试品溶液-1
图116　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-10min-片6-供试品溶液-1
图117　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-15min-片1-供试品溶液-1
图118　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-15min-片2-供试品溶液-1
图119　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-15min-片3-供试品溶液-1
图120　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-15min-片4-供试品溶液-1
图121　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-15min-片5-供试品溶液-1
图122　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-15min-片6-供试品溶液-1
图123　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-20min-片1-供试品溶液-1
图124　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-20min-片2-供试品溶液-1
图125　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-20min-片3-供试品溶液-1
图126　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-20min-片4-供试品溶液-1
图127　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-20min-片5-供试品溶液-1
图128　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-20min-片6-供试品溶液-1
图129　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-30min-片1-供试品溶液-1
图130　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-30min-片2-供试品溶液-1
图131　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-30min-片3-供试品溶液-1
图132　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-30min-片4-供试品溶液-1
图133　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-30min-片5-供试品溶液-1
图134　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-30min-片6-供试品溶液-1
图135　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-45min-片1-供试品溶液-1
图136　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-45min-片2-供试品溶液-1
图137　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-45min-片3-供试品溶液-1
图138　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-45min-片4-供试品溶液-1
图139　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-45min-片5-供试品溶液-1
图140　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-45min-片6-供试品溶液-1
图141　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-60min-片1-供试品溶液-1
图142　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-60min-片2-供试品溶液-1
图143　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-60min-片3-供试品溶液-1
图144　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-60min-片4-供试品溶液-1
图145　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-60min-片5-供试品溶液-1
图146　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-60min-片6-供试品溶液-1
图147　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-120min-片1-供试品溶液-1
图148　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-120min-片2-供试品溶液-1
图149　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-120min-片3-供试品溶液-1
图150　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-120min-片4-供试品溶液-1
图151　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-120min-片5-供试品溶液-1
图152　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-120min-片6-供试品溶液-1
图153　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-180min-片1-供试品溶液-1
图154　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-180min-片2-供试品溶液-1
图155　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-180min-片3-供试品溶液-1
图156　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-180min-片4-供试品溶液-1
图157　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-180min-片5-供试品溶液-1
图158　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-180min-片6-供试品溶液-1
图159　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-240min-片1-供试品溶液-1
图160　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-240min-片2-供试品溶液-1
图161　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-240min-片3-供试品溶液-1
图162　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-240min-片4-供试品溶液-1
图163　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-240min-片5-供试品溶液-1
图164　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-240min-片6-供试品溶液-1
图165　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-360min-片1-供试品溶液-1
图166　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-360min-片2-供试品溶液-1
图167　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-360min-片3-供试品溶液-1
图168　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-360min-片4-供试品溶液-1
图169　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-360min-片5-供试品溶液-1
图170　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-360min-片6-供试品溶液-1
图171　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-480min-片1-供试品溶液-1
图172　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-480min-片2-供试品溶液-1
图173　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-480min-片3-供试品溶液-1
图174　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-480min-片4-供试品溶液-1
图175　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-480min-片5-供试品溶液-1
图176　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-480min-片6-供试品溶液-1
图177　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-600min-片1-供试品溶液-1
图178　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-600min-片2-供试品溶液-1
图179　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-600min-片3-供试品溶液-1
图180　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-600min-片4-供试品溶液-1
图181　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-600min-片5-供试品溶液-1
图182　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-600min-片6-供试品溶液-1
图183　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-720min-片1-供试品溶液-1
图184　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-720min-片2-供试品溶液-1
图185　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-720min-片3-供试品溶液-1
图186　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-720min-片4-供试品溶液-1
图187　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-720min-片5-供试品溶液-1
图188　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-720min-片6-供试品溶液-1
图189　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-极限转速-片1-供试品溶液-1
图190　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-极限转速-片2-供试品溶液-1
图191　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-极限转速-片3-供试品溶液-1
图192　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-极限转速-片4-供试品溶液-1
图193　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-极限转速-片5-供试品溶液-1
图194　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-极限转速-片6-供试品溶液-1
图195　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-对照品溶液-2-1
图196　达格列净二甲双胍缓释片溶出曲线测定HPLC图谱-参比制剂-YA0011批-均一性2-pH6.8介质-篮法-100转-对照品溶液-2-2

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